| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 4/22/2008 12:28:41 PM | The April 20, 2008 broadcast of 60 minutes (CBS) aired the following segment:
It's pretty well known to doctors that the most successful treatment for obesity is surgery, especially the gastric bypass operation. But here's something the medical world is just realizing: that the gastric bypass operation has other even more dramatic effects. It can force type 2 diabetes into almost instant remission and it appears to reduce the risk of cancer.
Surgeons have been performing bariatric, or weight loss operations since the 1950s, but they're much safer than they used to be. They're typically done laparoscopically now, where doctors use tiny surgical tools and video cameras instead of making big, deep incisions.
Despite the increase in obesity, only a small number of people have had the gastric bypass operation.........
Studies confirm that about 80 percent of diabetics go into complete remission following the operation. Obesity is considered one of the major causes of type 2 diabetes, but here's something odd: when you have the gastric bypass operation, your diabetes goes away long before you lose the weight..........
This spontaneous remission puzzled Italian surgeon Francesco Rubino, now at New York Presbyterian Weill Cornell Medical Center. "We wanted to know what is making diabetes remit. We thought it could have been something to do with the small bowel," Dr. Rubino says.
So he began performing the bypass on diabetic rats, and realized that when he disconnected the top of the small intestine, an area called the duodenum, the diabetes disappeared. Then, he reversed the operation.
When he reattached it, the diabetes came back.
This was a pivotal discovery. By merely blocking food from traveling through the duodenum, Rubino sent diabetes into remission, proving the effect was independent from weight loss. This meant diabetes could essentially be removed with a scalpel.
Dr. Rubino says this operation has been performed on humans.
60 Minutes joined him in Sao Paulo, Brazil, where clinical trials have begun on diabetics who are not obese, to determine if the "diabetes surgery" is safe and effective.
As of now, if you have diabetes and are not obese you can't have the bypass surgery. Under guidelines written by the National Institutes of Health 17 years ago in 1991, only the severely or morbidly obese are eligible for any bariatric operation. If you're just mildly obese, you can't get it..........
The NIH told 60 Minutes there's no plan to revise the guidelines, but they are currently studying the benefits and risks of bypass surgery.
http://www.cbsnews.com/stories/2008/04/17/60minutes/main4023451.shtml
Clinical trials are underway in a number of areas ~ here's one in New Rochelle, New York
Study of Duodenal-Jejunal Bypass (DJB) as a Potential Cure for Type 2 Diabetes Mellitus
This study is currently recruiting participants.
Verified by Sound Shore Medical Center of Westchester, February 2008
Premise: Complete resolution of Type 2 Diabetes Mellitus with normalization of blood glucose and HbA1c in the abscence of medication support is possible with a surgical procedure named the "Duodenal-Jejunal Bypass (DJB)" a modification of an established duodenal switch procedure and is performed utilizing the laparoscopic approach.
Hypothesis: The duodenum plays a major role in glucose homeostasis through mechanisms largely unknown at this time. Evidence of this hypothesis comes from accumulated data in bariatric surgery patients who underwent Roux-en-y Gastric Bypass or Biliopancreatic Diversion (BPD) with or without a Duodenal Switch. Current evidence strongly supports this hypothesis with a long term (over 10 years) Type 2 Diabetes Mellitus(T2DM) resolution rate of 84-86% following the gastric bypass and over 95% for the duodenal switch.
The clinical resolution of T2DM is defined as independence of all anti-diabetic medications and maintaining a HbA1c less than 6.0. Recent rodent experiments by Francesco Rubino and subsequent human case reports by Cohen et al. supports the validity of this hypothesis. The modified procedure involved a roux-en-y bypass of the duodenum and 30-50cm of proximal jejunum, unaltering the stomach and pylorus resulted in resolution of T2DM with no weight loss in all subjects.
http://clinicaltrials.gov/ct2/show/NCT00562029?cond=%22Diabetes+Mellitus%22&rank=39
Wow ~ in my opinion, this research could rewrite the books on our current understanding of Type 2 diabetes. I find this fascinating and will be following published outcomes with interest ! Till then, I welcome your thoughts..... | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 4/22/2008 12:45:47 PM | | I'm sorry, I never reply to posts on here but this information is idiotic. It's not your fault, it's the medical establishment. One of the results of Gastric Bypass is the complete inability to handle or process most carbohydrates. The post-op protocol calls for abstinence from carbs, permanently. This puts the patient on the Atkins diet! It has long been known that low carb or no carb diets can put Type II into immediate remission. So - the surgery is totally superflous! Skip the knife, ditch the carbs and heal yourself! There is just no need to cut your stomach open. | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 4/22/2008 1:53:11 PM |
So - the surgery is totally superflous! Skip the knife, ditch the carbs and heal yourself! There is just no need to cut your stomach open.
A duodenal - jejunal bypass leaves the stomach intact ~ and the laparoscopic technique used means that only tiny incisions are made. Also, the clinical trial cited in my opening post does not allow the inclusion of morbidly and clinically obese participants. Inclusion criteria states that the body mass index must be LESS than 35.
Not ALL type 2 diabetics are overweight so I would surmise that "ditching the carbs" may not be entirely efficacious for them. | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 6/28/2008 6:08:48 AM | If you want to cure Type 2 Diabetes, just stop eating fried foods! Well, there's more to it than that, but seriously, diabetes is the cell's inability to receive insulin because the receptors are clogged by fatty oil. There are good oils, but most oils in the American diet are the bad kind. Sugar is only a problem when glucose cannot nourish the cell because the insulin enzyme can't break through the receptor in the cell wall to nourish the cell. Too much glucose outside the cells can create havoc in the body, leading to all those symptoms one experiences with a high sugar rate.
The best diet for Type 2 Diabetes is the Pritikin Diet.
By the way, that same principle applies with cancer, except it has to do with trophoblastic cells (the kind that grows hair, fingernails, repairs wounds and develops fetuses--rapid growth cells). T-cells are controlled by B-17 in the diet--found in the seeds and kernels of apples, pears, peaches, apricots, etc. (but you must eat the seed/kernel with the fruit or you can poison yourself). A lack of B-17 in the body can result in out of control T-cells, which (if the immune system is healthy) can result in benign tumors or (if the immune system is unhealthy) malignant tumors. L-tryptophane (found in bananas and turkey) is essential to create the enzyme trypsin to unlock the receptors of the T-cells and allow the B-17 to do its job--destroy the cell without harming the rest of the body. I learned this from some of my customers who were treated at the Cantreras Cancer Clinic in Mexico. That's why the AMA got the government to successfully ban Laetrile (B-17) and L-Tryptophane in the US. They make too much money off of cancer. And don't get me started on AIDS!!! | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 7/30/2008 12:34:16 PM |
The best diet for Type 2 Diabetes is the Pritikin Diet.
And Exersize,...dont forget about the exersize,......
You can substitute basicly any Diet plan,...in place of the "Pritikin Diet",... plan,..and it will work,....maybe not as good ,..but Exersize,..with any Diet plan, will give you better results, than No Diet plan,...and No Exersize.
Walking,..for 30 to 45 min's,..is a great way to get back into shape, its low impact,..you can set your own pace, and increase your pace as you improve,...
The benifits of Brisk Walking are Great,.Lower Blood Pressure,.Lower Blood Sugar,..
weight loss,..increased metabolism,..increased strength and staminia,..
And feeling better,....and sleeping better !
The Pritikin Diet is basicly what the Dr's have been telling me to do,.....cut out fried foods and red meat,..and increase eating fruits and veggies, and whole grains,....
And Exersize ! | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 9/6/2008 7:10:32 AM | Interesting thread, OP. Sounds like a cure for diabetes. But since the article says "The duodenum plays a major role in glucose homeostasis through mechanisms largely unknown at this time", it is clear that we cannot take it at face value. After all, science is all about theories. What good is a scientific discovery that cannot be explained?
So let's look further. First, we know that obese people have much higher rates of diabetes. However, if the duodenum was the issue, then we would expect equal rates of diabetes with obese and healthy-weighted people who both have duodenums, the normal status.
So it appears that obesity AND owning a duodenum raises your levels of diabetes much higher than normal.
So why would obesity have such a great effect on the duodenum?
1) Well, the duodenum is the place where most chemical digestion takes place. From personal experience, I know that not all food is digested and some gets through without digestion. So it is quite easy to see that if you eat food, most of it will not get digested because there is no duodenum to digest it in the first place.
2) As Imawriter said, people with Gastric Bypass surgery cannot have many carbs, and it is well-known that it is carbs that put on the weight that causes obesity. As the carbs are our source of glucose, and insulin is used to convert excess glucose into glycogen, sparing us the dangers of hyperglycemia and hypoglycemia, which are the real dangers of diabetes. So removing the carbs removes the excess glucose from entering our system, so we need far less insulin. Obesity is just another byproduct of ingesting too many carbs.
3) The duodenum is supplied digestive juices by the liver, the gall bladder, and the pancreas. But the pancreas also makes insulin. So the less digestive juices the pancreas has to make for the duodenum, the more resources it can devote to making insulin. Remove the duodenum, and no digestive juices are needed from the pancreas. No digestive juices are needed from the pancreas, and the pancreas can get on with its other job, that of producing insulin, glucagon (the complement of insulin), and somatostatin.
If you can believe it, there are many healthy people who eat only 1200 calories a day, and obese people who eat over 8000 calories a day. So effectively, for those obese people, you would need 6.5 pancreases just to deal with the amount of food they eat and not stress out the pancreas any more than the healthy people. You need the same amount of insulin to convert it all to glycogen. So effectively, the pancreas of obese people can be working as much as 6.5 times as hard as the pancreas of healthy people. Over years, that drain the pancrease, and it just cannot work as hard. So there is less and less good-quality insulin.
But cut out the duodenum, and the pancreas completely drops one of those jobs. As digestive enzymes act directly on food, the more food, the more enzymes you need, and in proportion. But insulin is a hormone. It signals to the liver to store glucose, so the amount of insulin you need is not nearly as much as the glucose you need to store. So the vast majority of production of the pancreas is devoted to these enzymes, and not insulin, so cut out the duodenum, and the pancreas has cut out the vast majority of its workload. Like you going from an 40-hour week to a 300-hour week, and then cut it back to a 2-hour week. Even if you're completely shattered, it is 1/150th of what you were doing, so it's easy, and in a few days, you'll feel right as rain.
There seem to be lots of reasons why this surgery should be effective. But they all seem to base around the idea that insulin is used to signal the body to store excess ingested calories, so controlling your calorie intake seems to be the solution, and the removal of the duodenum would limit your ability to ingest calories.
But then, it would be like removing a lung, or a leg. You'll still live without them. But your body will be impaired. You will need to eat differently, and at different times, and watch what you eat a whole lot more.
As Imawriter said, you might as well do that first, and then you don't need to mess up your body.
P.S. they studied the longest-lived people in the world. One of them are the Okinawans. They regularly live to over 100. They often work into their late 90s. They have almost no incidence of diabetes, but also almost no incidence of heart disease, and most cancers that are so prevalent over here.
One of the 3 things they do is that they have a saying "stop eating when you are 80% full". They eat far less calories than even Western doctors recommend. Yet they are in far better shape than even the best of us in the West.
They know it's not genetic, but environmental, because Okinawans who moved to Hawaii and who adopted Western eating habits, and even native Okinawans who adopted Western eating habits on Okinawa, swiftly develop the same problems and shortness of lifespan that we have.
Doctors aren't really sure why. But they are sure that it works. For this reason, doctors have already been prescribing caloric restriction as a health measure for at least 6 months, and probably longer. It's just that I'm sure the program was made at least 6 months ago.
So eating less calories does a lot more than cure diabetes. | |
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| Duodenal-Jejunal Bypass ~ a Potential Cure for Type 2 diabetes ???
Posted: 9/6/2008 7:26:46 AM | Gymnema sylvestre is also referred to as “gurmar,” which means “destroyer of sugar” in Hindi. The name comes from the way the leaves, when chewed, interfere with your ability to taste sweetness. But as you’ll now see, Gymnema sylvestre does so much more.
In recent years, scientists and doctors have begun to study the marvelous health-giving effects of Gymnema sylvestre. And here’s what we now know. This remarkable herb helps…
• Balance your fasting blood sugar level
• Control your hemoglobin A1c levels (average blood sugar for three months)
• Improve your body’s glycemic control
• Increase the effectiveness of insulin
These benefits are possible because Gymnema sylvestre:
1. Contains gymnemic acids, which are known to suppress absorption of glucose in your blood stream
2. Assists your pancreas in producing more insulin to balance blood sugar
3. Decreases the sensation of sweetness in many foods
Those taking chromium showed significant improvement in insulin sensitivity at four and eight months—plus, no change in body fat distribution. This suggests that chromium can beneficially affect your insulin, independent of changes in your weight or body fat.
Traditionally, people have brewed a banaba leaf tea to help control blood sugar, and it’s hailed as a medicinal plant among natural healers.
Medical scientists believe that banaba leaf’s beneficial effects on blood sugar are due to its high concentration of corosolic acid, a natural compound extracted from its leaves.
The fourth exclusive ingredient in the new Advanced Blood Sugar Solution™ is a food and spice prized in many parts of the world: Fenugreek seed.
For more than 2,000 years, fenugreek seed has been used by practitioners of Ayurvedic and traditional Chinese medicine.
But it’s come to the forefront the past two decades because research shows it helps balance your blood sugar, cholesterol and triglycerides.
cinnamon actually increases glucose metabolism—the process your cells use to convert glucose to energy.
Unknown to most people in the West, bitter melon has long been used in South America and the Orient as a food and natural medicine.
But we doctors began to pay special attention to it when scientific studies revealed its marvelous benefits on blood sugar.
As a “kicker,” this unique formula also includes policosanol.
Made from the wax of sugar cane, policosanol has made headline news because of its positive effects on cholesterol. And because so many people who worry about their blood sugar also worry about their cholesterol, adding policosanol to the Advanced Blood Sugar Solution™ was a stroke of genius.
Policosanol is hailed as nature’s No. 1 cholesterol breakthrough because it helps block synthesis of bad cholesterol and helps keep your heart and arteries healthy.
What’s more, it helps keep cholesterol healthy without impairing glycemic control—which is great news if you’re concerned about your blood sugar.
In one eye-opening study,(17) 239 patients with blood sugar concerns took 5 mg a day of policosanol or a placebo for two years, following five weeks of a step-one cholesterol-lowering diet. | |
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